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Rao, K. N. V.
- Alpha-glucosidase Inhibitory and Hypoglycemic Activities of Piper trioicum Extract
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Journal of Natural Remedies, Vol 11, No 1 (2011), Pagination: 31-38Abstract
Alpha glucosidase in vitro inhibitory activity and hypoglycemic effect by oral administration in rats of Piper trioicum ethanol extracts have been investigated. Piper trioicum extract showed in vitro inhibitory activity of intestinal alpha glucosiadse enzyme maltase. Analysis of data confirms that alpha glucosidase inhibition activity was maximum at 500 mcg/ml of Piper trioicum. The purpose of study was to know whether Piper trioicum extract could reduce intestinal absorption of monosaccharides by inhibiting disaccharide hydrolysis. The post prandial elevation in blood glucose level at 60 and 120 min after administration of maltose with Piper trioicum extracts (200 mg/kg and 400 mg/kg doses) showed significant suppression compared to control group. These results suggest that the Piper trioicum extract has potent alpha glucosidase inhibitory activity and would be effective in suppression of elevation in blood glucose after oral administration of maltose to rats.Keywords
Piper trioicum, Hypoglycemic Activity, Alpha-glucosidase InhibitionFull Text
- Alpha-Glucosidase Inhibitory Activities of Wrightia tinctoria Roxb and Schrebera swietenoides Roxb Bark Extract
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Affiliations
1 Fathima Institute of Pharmacy, Ramarajupalli, Kadapa, Andhra Pradesh, IN
2 Department of Pharmacognosy, Nalanda College of Pharmacy, Nalgonda, Andhra Pradesh, IN
3 Nalanda College of Pharmacy, Nalgonda, Andhra Pradesh, IN
1 Fathima Institute of Pharmacy, Ramarajupalli, Kadapa, Andhra Pradesh, IN
2 Department of Pharmacognosy, Nalanda College of Pharmacy, Nalgonda, Andhra Pradesh, IN
3 Nalanda College of Pharmacy, Nalgonda, Andhra Pradesh, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 3, No 1 (2011), Pagination: 22-24Abstract
Alpha glucosidase inhibitory activities of Wrightia tinctoria Roxb and Schrebera swietenoides Roxb ethanol extracts were investigated individually. Wrightia tinctoria Roxb and Schrebera swietenoides Roxb bark extract showed in-vitro inhibitory activity of intestinal alpha glucosidase enzyme maltase. Analysis of data confirms that alpha glucosidase inhibition activity was the maximum at 1500mcg/ml of Wrightia tinctoria Roxb bark and 2000mcg/ml of Schrebera swietenoides Roxb bark. The purpose of study was to know whether Wrightia tinctoria Roxb bark and Schrebera swietenoides Roxb bark extract could reduce intestinal absorption of monosaccharides by inhibiting disaccharide hydrolysis. These results suggest that the Wrightia tinctoria Roxb bark extract and Schrebera swietenoides Roxb bark has little potent alpha glucosidase inhibitory activity individually and would be effective in suppression of elevation in blood glucose.Keywords
Wrightia tinctoria Roxb, Schrebera swietenoides Roxb, Maltase, Acarbose.
References
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- Supercritical Fluid Extraction (SFE)-An Overview
Abstract Views :312 |
PDF Views:6
Authors
Affiliations
1 Nalada College of Pharmacy, Charlapally, Hyderabad Road, Nalgonda-508001 Andhra Pradesh, IN
1 Nalada College of Pharmacy, Charlapally, Hyderabad Road, Nalgonda-508001 Andhra Pradesh, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 2, No 3 (2012), Pagination: 112-120Abstract
Among the different extraction techniques used at analytical and preparative scale, supercritical fluid extraction (SFE) is one of the most used separation technique, which mostly depends on critical temperature and pressure of supercritical fluid. This review covers the most recent developments of SFE indifferent fields (SFE applications), such as food science, natural products, by-product recovery, pharmaceutical and environmental sciences, during the period 2007-2009. The revision is focused on the most recent advances and applications in the different areas; among them, it is remarkable the strong impact of SFE to extract high value compounds from food and various natural products but also its increasing importance in areas such as heavy metals recovery, enantiomeric resolution or drug delivery systems.Keywords
Super Critical Fluid Extraction, Critical Temperature, Critical Pressure, Supercritical Fluid, Food Science, Natural Products.References
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- RP-HPLC Method Development and Validation for Estimation of Sofosbuvir in Pure and Tablet Dosage Form
Abstract Views :184 |
PDF Views:0
Authors
Affiliations
1 Nalanda College of Pharmacy, Charlapally, Nalgonda, Telangana, IN
1 Nalanda College of Pharmacy, Charlapally, Nalgonda, Telangana, IN
Source
Asian Journal of Pharmacy and Technology, Vol 7, No 3 (2017), Pagination: 153-156Abstract
A rapid and precise Reverse Phase High Performance Liquid Chromatographic method has been developed for the validation of Sofosbuvir, in its pure form as well as in tablet dosage form. Chromatography was carried out on a Hypersil C18 (4.6×150mm, 5μ) column using a mixture of Methanol (100% v/v) as the mobile phase at a flow rate of 1.0 mL/min, the detection was carried out at 265 nm. The retention time of the Sofosbuvir was 3.515 ±0.02min. The method produce linear responses in the concentration range of 20-100μg/mL of Sofosbuvir. The method precision for the determination of assay was below 2.0% RSD. The method is useful in the quality control of bulk and pharmaceutical formulations.Keywords
Sofosbuvir, RP-HPLC, Validation, Tablet Dosage Forms.References
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